home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 308.4 KB |
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MacOS 8.1
|
Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 8e 05 00 00 |......00|........|
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|000003d0| 00 00 00 01 f5 2f 03 00 | 87 0c 00 00 37 30 00 00 |...../..|....70..|
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|00000410| 08 0d 00 00 37 34 00 00 | 00 01 a1 7a 03 00 a1 0b |....74..|...z....|
|00000420| 00 00 37 35 00 00 00 01 | 42 86 03 00 86 0e 00 00 |..75....|B.......|
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|00000460| 5b be 03 00 24 0c 00 00 | 38 30 00 00 00 01 7f ca |[...$...|80......|
|00000470| 03 00 81 10 00 00 38 31 | 00 00 00 01 00 db 03 00 |......81|........|
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|00000490| 00 00 38 33 00 00 00 01 | 3f f0 03 00 46 0e 00 00 |..83....|?...F...|
|000004a0| 38 34 00 00 00 01 85 fe | 03 00 09 0d 00 00 38 35 |84......|......85|
|000004b0| 00 00 00 01 8e 0b 04 00 | 5c 0a 00 00 38 36 00 00 |........|\...86..|
|000004c0| 00 01 ea 15 04 00 db 0a | 00 00 38 37 00 00 00 01 |........|..87....|
|000004d0| c5 20 04 00 d5 0c 00 00 | 38 38 00 00 00 01 9a 2d |. ......|88.....-|
|000004e0| 04 00 82 10 00 00 38 39 | 00 00 00 01 1c 3e 04 00 |......89|.....>..|
|000004f0| 55 0b 00 00 39 30 00 00 | 00 01 71 49 04 00 08 0b |U...90..|..qI....|
|00000500| 00 00 39 31 00 00 00 01 | 79 54 04 00 68 12 00 00 |..91....|yT..h...|
|00000510| 39 32 00 00 00 01 e1 66 | 04 00 4e 10 00 00 39 33 |92.....f|..N...93|
|00000520| 00 00 00 01 2f 77 04 00 | 71 0f 00 00 39 34 00 00 |..../w..|q...94..|
|00000530| 00 01 a0 86 04 00 87 0b | 00 00 39 35 00 00 00 01 |........|..95....|
|00000540| 27 92 04 00 7c 0e 00 00 | 39 36 00 00 00 01 a3 a0 |'...|...|96......|
|00000550| 04 00 04 0a 00 00 39 37 | 00 00 00 01 a7 aa 04 00 |......97|........|
|00000560| 04 10 00 00 39 38 00 00 | 00 01 ab ba 04 00 32 0c |....98..|......2.|
|00000570| 00 00 39 39 00 00 00 01 | dd c6 04 00 e8 0a 00 00 |..99....|........|
|00000580| 00 00 00 00 00 00 c5 d1 | 04 00 00 00 00 00 24 55 |........|......$U|
|00000590| 6e 69 71 75 65 5f 49 44 | 7b 59 52 42 30 35 36 30 |nique_ID|{YRB0560|
|000005a0| 30 7d 0d 0a 24 54 69 74 | 6c 65 7b 50 72 65 76 61 |0}..$Tit|le{Preva|
|000005b0| 6c 65 6e 63 65 2c 20 50 | 61 74 68 6f 67 65 6e 65 |lence, P|athogene|
|000005c0| 73 69 73 2c 20 61 6e 64 | 20 54 72 65 61 74 6d 65 |sis, and| Treatme|
|000005d0| 6e 74 20 6f 66 20 52 65 | 6e 61 6c 20 44 79 73 66 |nt of Re|nal Dysf|
|000005e0| 75 6e 63 74 69 6f 6e 20 | 41 73 73 6f 63 69 61 74 |unction |Associat|
|000005f0| 65 64 20 57 69 74 68 20 | 43 68 72 6f 6e 69 63 20 |ed With |Chronic |
|00000600| 4c 69 74 68 69 75 6d 20 | 54 68 65 72 61 70 79 7d |Lithium |Therapy}|
|00000610| 0d 0a 24 41 75 74 68 6f | 72 7b 0d 0a 42 6f 74 6f |..$Autho|r{..Boto|
|00000620| 6e 2c 20 52 0d 0a 47 61 | 76 69 72 69 61 2c 20 4d |n, R..Ga|viria, M|
|00000630| 0d 0a 42 61 74 6c 6c 65 | 2c 20 44 43 7d 0d 0a 24 |..Batlle|, DC}..$|
|00000640| 41 66 66 69 6c 69 61 74 | 69 6f 6e 7b 55 6e 69 76 |Affiliat|ion{Univ|
|00000650| 20 6f 66 20 49 6c 6c 69 | 6e 6f 69 73 20 61 74 20 | of Illi|nois at |
|00000660| 43 68 69 63 61 67 6f 3b | 20 4e 6f 72 74 68 77 65 |Chicago;| Northwe|
|00000670| 73 74 65 72 6e 20 55 6e | 69 76 7d 0d 0a 24 53 75 |stern Un|iv}..$Su|
|00000680| 62 6a 65 63 74 7b 4c 69 | 74 68 69 75 6d 20 6b 69 |bject{Li|thium ki|
|00000690| 64 6e 65 79 20 61 66 74 | 65 72 20 70 72 65 76 61 |dney aft|er preva|
|000006a0| 6c 65 6e 63 65 2c 20 70 | 61 74 68 6f 67 65 6e 65 |lence, p|athogene|
|000006b0| 73 69 73 20 61 6e 64 20 | 74 72 65 61 74 6d 65 6e |sis and |treatmen|
|000006c0| 74 20 6f 66 20 74 68 65 | 20 72 65 6e 61 6c 20 64 |t of the| renal d|
|000006d0| 79 73 66 75 6e 63 74 69 | 6f 6e 7d 0d 0a 24 4a 6f |ysfuncti|on}..$Jo|
|000006e0| 75 72 6e 61 6c 7b 41 6d | 20 4a 20 4b 69 64 6e 65 |urnal{Am| J Kidne|
|000006f0| 79 20 44 69 73 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b |y Dis}..|$Volume{|
|00000700| 31 30 7d 0d 0a 24 50 61 | 67 65 7b 33 32 39 2d 33 |10}..$Pa|ge{329-3|
|00000710| 34 35 7d 0d 0a 24 44 61 | 74 65 7b 4e 6f 76 65 6d |45}..$Da|te{Novem|
|00000720| 62 65 72 20 31 39 38 37 | 7d 0d 0a 24 59 42 56 6f |ber 1987|}..$YBVo|
|00000730| 6c 7b 31 39 38 39 20 59 | 65 61 72 20 42 6f 6f 6b |l{1989 Y|ear Book|
|00000740| 20 6f 66 20 44 72 75 67 | 20 54 68 65 72 61 70 79 | of Drug| Therapy|
|00000750| 7d 0d 0a 24 43 68 61 70 | 74 65 72 7b 33 2d 31 38 |}..$Chap|ter{3-18|
|00000760| 7d 0d 0a 24 59 42 45 64 | 69 74 6f 72 7b 44 72 73 |}..$YBEd|itor{Drs|
|00000770| 2e 20 48 6f 6c 6c 69 73 | 74 65 72 20 61 6e 64 20 |. Hollis|ter and |
|00000780| 4c 61 73 61 67 6e 61 7d | 0d 0a 24 54 61 62 6c 65 |Lasagna}|..$Table|
|00000790| 7b 7d 0d 0a 24 43 6f 6d | 6d 65 6e 74 61 74 6f 72 |{}..$Com|mentator|
|000007a0| 7b 4c 2e 20 4c 61 73 61 | 67 6e 61 2c 20 4d 2e 44 |{L. Lasa|gna, M.D|
|000007b0| 2e 7d 0d 0a 0d 0a 43 6f | 70 79 72 69 67 68 74 20 |.}....Co|pyright |
|000007c0| 28 63 29 20 59 65 61 72 | 20 42 6f 6f 6b 20 4d 65 |(c) Year| Book Me|
|000007d0| 64 69 63 61 6c 20 50 75 | 62 6c 69 73 68 65 72 73 |dical Pu|blishers|
|000007e0| 2c 20 49 6e 63 2e 2c 20 | 31 39 38 39 0d 0a 0d 0a |, Inc., |1989....|
|000007f0| 31 39 38 39 20 59 65 61 | 72 20 42 6f 6f 6b 20 6f |1989 Yea|r Book o|
|00000800| 66 20 44 72 75 67 20 54 | 68 65 72 61 70 79 20 28 |f Drug T|herapy (|
|00000810| 52 29 0d 0a 0d 0a 43 68 | 61 70 74 65 72 20 33 2d |R)....Ch|apter 3-|
|00000820| 2d 41 64 76 65 72 73 65 | 20 44 72 75 67 20 52 65 |-Adverse| Drug Re|
|00000830| 61 63 74 69 6f 6e 73 0d | 0a 0d 0a 2d 2d 2d 2d 2d |actions.|...-----|
|00000840| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000850| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000860| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000870| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000880| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 50 72 65 |--------|---..Pre|
|00000890| 76 61 6c 65 6e 63 65 2c | 20 50 61 74 68 6f 67 65 |valence,| Pathoge|
|000008a0| 6e 65 73 69 73 2c 20 61 | 6e 64 20 54 72 65 61 74 |nesis, a|nd Treat|
|000008b0| 6d 65 6e 74 20 6f 66 20 | 52 65 6e 61 6c 20 44 79 |ment of |Renal Dy|
|000008c0| 73 66 75 6e 63 74 69 6f | 6e 20 41 73 73 6f 63 69 |sfunctio|n Associ|
|000008d0| 61 74 65 64 20 57 69 74 | 68 0d 0a 43 68 72 6f 6e |ated Wit|h..Chron|
|000008e0| 69 63 20 4c 69 74 68 69 | 75 6d 20 54 68 65 72 61 |ic Lithi|um Thera|
|000008f0| 70 79 0d 0a 0d 0a 42 6f | 74 6f 6e 20 52 2c 20 47 |py....Bo|ton R, G|
|00000900| 61 76 69 72 69 61 20 4d | 2c 20 42 61 74 6c 6c 65 |aviria M|, Batlle|
|00000910| 20 44 43 0d 0a 28 55 6e | 69 76 20 6f 66 20 49 6c | DC..(Un|iv of Il|
|00000920| 6c 69 6e 6f 69 73 20 61 | 74 20 43 68 69 63 61 67 |linois a|t Chicag|
|00000930| 6f 3b 20 4e 6f 72 74 68 | 77 65 73 74 65 72 6e 20 |o; North|western |
|00000940| 55 6e 69 76 29 0d 0a 41 | 6d 20 4a 20 4b 69 64 6e |Univ)..A|m J Kidn|
|00000950| 65 79 20 44 69 73 20 31 | 30 3a 33 32 39 2d 33 34 |ey Dis 1|0:329-34|
|00000960| 35 2c 20 4e 6f 76 65 6d | 62 65 72 20 31 39 38 37 |5, Novem|ber 1987|
|00000970| 0d 0a 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |..------|--------|
|00000980| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000990| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000009a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000009b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000009c0| 2d 2d 0d 0a 0d 0a 41 62 | 73 74 72 61 63 74 0d 0a |--....Ab|stract..|
|000009d0| 0d 0a 20 20 20 20 20 45 | 78 70 65 72 69 65 6e 63 |.. E|xperienc|
|000009e0| 65 20 77 69 74 68 20 31 | 2c 31 37 32 20 6c 69 74 |e with 1|,172 lit|
|000009f0| 68 69 75 6d 2d 74 72 65 | 61 74 65 64 20 70 61 74 |hium-tre|ated pat|
|00000a00| 69 65 6e 74 73 20 69 6e | 64 69 63 61 74 65 73 20 |ients in|dicates |
|00000a10| 74 68 61 74 20 69 6d 70 | 61 69 72 65 64 0d 0a 63 |that imp|aired..c|
|00000a20| 6f 6e 63 65 6e 74 72 61 | 74 69 6e 67 20 61 62 69 |oncentra|ting abi|
|00000a30| 6c 69 74 79 20 69 73 20 | 74 68 65 20 6d 6f 73 74 |lity is |the most|
|00000a40| 20 70 72 65 76 61 6c 65 | 6e 74 20 72 65 6e 61 6c | prevale|nt renal|
|00000a50| 20 65 66 66 65 63 74 20 | 6f 66 20 6c 69 74 68 69 | effect |of lithi|
|00000a60| 75 6d 2e 20 20 4d 6f 72 | 65 20 74 68 61 6e 0d 0a |um. Mor|e than..|
|00000a70| 68 61 6c 66 20 6f 66 20 | 31 2c 31 30 35 20 75 6e |half of |1,105 un|
|00000a80| 73 65 6c 65 63 74 65 64 | 20 70 61 74 69 65 6e 74 |selected| patient|
|00000a90| 73 20 72 65 63 65 69 76 | 69 6e 67 20 6c 6f 6e 67 |s receiv|ing long|
|00000aa0| 2d 74 65 72 6d 20 74 72 | 65 61 74 6d 65 6e 74 20 |-term tr|eatment |
|00000ab0| 68 61 64 20 73 75 63 68 | 0d 0a 69 6d 70 61 69 72 |had such|..impair|
|00000ac0| 6d 65 6e 74 2c 20 62 75 | 74 20 6f 6e 6c 79 20 31 |ment, bu|t only 1|
|00000ad0| 39 25 20 68 61 64 20 6f | 76 65 72 74 20 70 6f 6c |9% had o|vert pol|
|00000ae0| 79 75 72 69 61 2e 20 20 | 54 68 65 20 64 65 66 65 |yuria. |The defe|
|00000af0| 63 74 20 69 6e 20 77 61 | 74 65 72 20 70 72 65 73 |ct in wa|ter pres|
|00000b00| 65 72 76 61 74 69 6f 6e | 0d 0a 61 70 70 61 72 65 |ervation|..appare|
|00000b10| 6e 74 6c 79 20 72 65 66 | 6c 65 63 74 73 20 69 6e |ntly ref|lects in|
|00000b20| 74 72 61 63 65 6c 6c 75 | 6c 61 72 20 6c 69 74 68 |tracellu|lar lith|
|00000b30| 69 75 6d 20 61 63 63 75 | 6d 75 6c 61 74 69 6f 6e |ium accu|mulation|
|00000b40| 20 69 6e 20 74 68 65 20 | 63 6f 6c 6c 65 63 74 69 | in the |collecti|
|00000b50| 6e 67 0d 0a 74 75 62 75 | 6c 65 73 2c 20 61 6c 74 |ng..tubu|les, alt|
|00000b60| 68 6f 75 67 68 20 63 65 | 6e 74 72 61 6c 20 64 69 |hough ce|ntral di|
|00000b70| 61 62 65 74 65 73 20 69 | 6e 73 69 70 69 64 75 73 |abetes i|nsipidus|
|00000b80| 20 61 6e 64 20 70 72 69 | 6d 61 72 79 20 70 6f 6c | and pri|mary pol|
|00000b90| 79 64 69 70 73 69 61 20 | 6d 61 79 0d 0a 63 6f 6e |ydipsia |may..con|
|00000ba0| 74 72 69 62 75 74 65 2e | 20 20 49 74 20 69 73 20 |tribute.| It is |
|00000bb0| 6e 6f 74 20 63 6c 65 61 | 72 20 77 68 65 74 68 65 |not clea|r whethe|
|00000bc0| 72 20 73 70 65 63 69 66 | 69 63 20 63 68 72 6f 6e |r specif|ic chron|
|00000bd0| 69 63 20 74 75 62 75 6c | 6f 2d 69 6e 74 65 72 73 |ic tubul|o-inters|
|00000be0| 74 69 74 69 61 6c 0d 0a | 63 68 61 6e 67 65 73 20 |titial..|changes |
|00000bf0| 72 65 73 75 6c 74 20 66 | 72 6f 6d 20 6c 69 74 68 |result f|rom lith|
|00000c00| 69 75 6d 20 74 72 65 61 | 74 6d 65 6e 74 2e 20 20 |ium trea|tment. |
|00000c10| 41 6d 69 6c 6f 72 69 64 | 65 20 63 61 6e 20 70 72 |Amilorid|e can pr|
|00000c20| 65 76 65 6e 74 20 6c 69 | 74 68 69 75 6d 20 75 70 |event li|thium up|
|00000c30| 74 61 6b 65 20 69 6e 0d | 0a 68 69 67 68 2d 72 65 |take in.|.high-re|
|00000c40| 73 69 73 74 61 6e 63 65 | 20 65 70 69 74 68 65 6c |sistance| epithel|
|00000c50| 69 61 2c 20 70 72 65 76 | 65 6e 74 69 6e 67 20 69 |ia, prev|enting i|
|00000c60| 74 73 20 69 6e 68 69 62 | 69 74 6f 72 79 20 65 66 |ts inhib|itory ef|
|00000c70| 66 65 63 74 20 6f 6e 20 | 77 61 74 65 72 20 74 72 |fect on |water tr|
|00000c80| 61 6e 73 70 6f 72 74 2e | 0d 0a 20 20 20 20 20 54 |ansport.|.. T|
|00000c90| 68 65 20 67 6c 6f 6d 65 | 72 75 6c 61 72 20 66 69 |he glome|rular fi|
|00000ca0| 6c 74 72 61 74 69 6f 6e | 20 72 61 74 65 20 77 61 |ltration| rate wa|
|00000cb0| 73 20 6e 6f 72 6d 61 6c | 20 69 6e 20 38 35 25 20 |s normal| in 85% |
|00000cc0| 6f 66 20 75 6e 73 65 6c | 65 63 74 65 64 20 70 61 |of unsel|ected pa|
|00000cd0| 74 69 65 6e 74 73 20 6f | 6e 0d 0a 63 68 72 6f 6e |tients o|n..chron|
|00000ce0| 69 63 20 6c 69 74 68 69 | 75 6d 20 74 68 65 72 61 |ic lithi|um thera|
|00000cf0| 70 79 2e 20 20 54 68 65 | 20 6f 74 68 65 72 73 20 |py. The| others |
|00000d00| 68 61 64 20 6f 6e 6c 79 | 20 61 20 6d 69 6c 64 20 |had only| a mild |
|00000d10| 72 65 64 75 63 74 69 6f | 6e 20 69 6e 20 67 6c 6f |reductio|n in glo|
|00000d20| 6d 65 72 75 6c 61 72 0d | 0a 66 69 6c 74 72 61 74 |merular.|.filtrat|
|00000d30| 69 6f 6e 2e 20 20 49 74 | 20 73 65 65 6d 73 20 75 |ion. It| seems u|
|00000d40| 6e 6c 69 6b 65 6c 79 20 | 74 68 61 74 20 6c 6f 6e |nlikely |that lon|
|00000d50| 67 2d 74 65 72 6d 20 6c | 69 74 68 69 75 6d 20 74 |g-term l|ithium t|
|00000d60| 72 65 61 74 6d 65 6e 74 | 20 77 69 6c 6c 20 6c 65 |reatment| will le|
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|00001490| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00002880| 70 72 69 6c 20 31 39 38 | 38 7d 0d 0a 24 59 42 56 |pril 198|8}..$YBV|
|00002890| 6f 6c 7b 31 39 38 39 20 | 59 65 61 72 20 42 6f 6f |ol{1989 |Year Boo|
|000028a0| 6b 20 6f 66 20 44 72 75 | 67 20 54 68 65 72 61 70 |k of Dru|g Therap|
|000028b0| 79 7d 0d 0a 24 43 68 61 | 70 74 65 72 7b 33 2d 32 |y}..$Cha|pter{3-2|
|000028c0| 31 7d 0d 0a 24 59 42 45 | 64 69 74 6f 72 7b 44 72 |1}..$YBE|ditor{Dr|
|000028d0| 73 2e 20 48 6f 6c 6c 69 | 73 74 65 72 20 61 6e 64 |s. Holli|ster and|
|000028e0| 20 4c 61 73 61 67 6e 61 | 7d 0d 0a 24 54 61 62 6c | Lasagna|}..$Tabl|
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|00002910| 2e 45 2e 20 48 6f 6c 6c | 69 73 74 65 72 2c 20 4d |.E. Holl|ister, M|
|00002920| 2e 44 2e 7d 0d 0a 0d 0a | 43 6f 70 79 72 69 67 68 |.D.}....|Copyrigh|
|00002930| 74 20 28 63 29 20 59 65 | 61 72 20 42 6f 6f 6b 20 |t (c) Ye|ar Book |
|00002940| 4d 65 64 69 63 61 6c 20 | 50 75 62 6c 69 73 68 65 |Medical |Publishe|
|00002950| 72 73 2c 20 49 6e 63 2e | 2c 20 31 39 38 39 0d 0a |rs, Inc.|, 1989..|
|00002960| 0d 0a 31 39 38 39 20 59 | 65 61 72 20 42 6f 6f 6b |..1989 Y|ear Book|
|00002970| 20 6f 66 20 44 72 75 67 | 20 54 68 65 72 61 70 79 | of Drug| Therapy|
|00002980| 20 28 52 29 0d 0a 0d 0a | 43 68 61 70 74 65 72 20 | (R)....|Chapter |
|00002990| 33 2d 2d 41 64 76 65 72 | 73 65 20 44 72 75 67 20 |3--Adver|se Drug |
|000029a0| 52 65 61 63 74 69 6f 6e | 73 0d 0a 0d 0a 2d 2d 2d |Reaction|s....---|
|000029b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 53 |--------|-----..S|
|00002a00| 65 78 75 61 6c 20 53 79 | 6d 70 74 6f 6d 73 20 69 |exual Sy|mptoms i|
|00002a10| 6e 20 48 79 70 65 72 74 | 65 6e 73 69 76 65 20 50 |n Hypert|ensive P|
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|00002a30| 69 63 61 6c 20 54 72 69 | 61 6c 20 6f 66 20 41 6e |ical Tri|al of An|
|00002a40| 74 69 68 79 70 65 72 74 | 65 6e 73 69 76 65 0d 0a |tihypert|ensive..|
|00002a50| 4d 65 64 69 63 61 74 69 | 6f 6e 73 0d 0a 0d 0a 43 |Medicati|ons....C|
|00002a60| 72 6f 6f 67 20 53 48 2c | 20 4c 65 76 69 6e 65 20 |roog SH,| Levine |
|00002a70| 53 2c 20 53 75 64 69 6c | 6f 76 73 6b 79 20 41 2c |S, Sudil|ovsky A,|
|00002a80| 20 42 61 75 6d 65 20 52 | 4d 2c 20 43 6c 69 76 65 | Baume R|M, Clive|
|00002a90| 20 4a 0d 0a 28 55 6e 69 | 76 20 6f 66 20 43 6f 6e | J..(Uni|v of Con|
|00002aa0| 6e 65 63 74 69 63 75 74 | 2c 20 46 61 72 6d 69 6e |necticut|, Farmin|
|00002ab0| 67 74 6f 6e 3b 20 42 6f | 73 74 6f 6e 20 55 6e 69 |gton; Bo|ston Uni|
|00002ac0| 76 3b 20 53 71 75 69 62 | 62 20 49 6e 73 74 20 66 |v; Squib|b Inst f|
|00002ad0| 6f 72 20 4d 65 64 20 52 | 65 73 65 61 72 63 68 2c |or Med R|esearch,|
|00002ae0| 0d 0a 50 72 69 6e 63 65 | 74 6f 6e 2c 20 4e 4a 3b |..Prince|ton, NJ;|
|00002af0| 20 4e 65 77 20 59 6f 72 | 6b 20 55 6e 69 76 29 0d | New Yor|k Univ).|
|00002b00| 0a 41 72 63 68 20 49 6e | 74 65 72 6e 20 4d 65 64 |.Arch In|tern Med|
|00002b10| 20 31 34 38 3a 37 38 38 | 2d 37 39 34 2c 20 41 70 | 148:788|-794, Ap|
|00002b20| 72 69 6c 20 31 39 38 38 | 0d 0a 2d 2d 2d 2d 2d 2d |ril 1988|..------|
|00002b30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 0d 0a 41 62 |--------|--....Ab|
|00002b80| 73 74 72 61 63 74 0d 0a | 0d 0a 20 20 20 20 20 57 |stract..|.. W|
|00002b90| 69 74 68 64 72 61 77 61 | 6c 20 66 72 6f 6d 20 74 |ithdrawa|l from t|
|00002ba0| 72 65 61 74 6d 65 6e 74 | 20 62 65 63 61 75 73 65 |reatment| because|
|00002bb0| 20 6f 66 20 61 64 76 65 | 72 73 65 20 64 72 75 67 | of adve|rse drug|
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|00002bd0| 61 6c 0d 0a 70 65 72 66 | 6f 72 6d 61 6e 63 65 20 |al..perf|ormance |
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|00002c00| 63 6f 6d 70 6c 69 61 6e | 63 65 20 77 69 74 68 20 |complian|ce with |
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|00002c90| 75 62 6c 65 2d 62 6c 69 | 6e 64 20 74 72 69 61 6c |uble-bli|nd trial|
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|00002e70| 41 6d 6f 6e 67 0d 0a 70 | 61 74 69 65 6e 74 73 20 |Among..p|atients |
|00002e80| 75 6e 64 65 72 67 6f 69 | 6e 67 20 6d 6f 6e 6f 74 |undergoi|ng monot|
|00002e90| 68 65 72 61 70 79 20 77 | 69 74 68 20 61 20 64 69 |herapy w|ith a di|
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|00002eb0| 79 6d 70 74 6f 6d 73 20 | 77 6f 72 73 65 6e 65 64 |ymptoms |worsened|
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|00002f40| 62 73 65 72 76 61 74 69 | 6f 6e 20 70 65 72 69 6f |bservati|on perio|
|00002f50| 64 2e 0d 0a 20 20 20 20 | 20 49 74 20 69 73 20 69 |d... | It is i|
|00002f60| 6d 70 6f 72 74 61 6e 74 | 20 74 6f 20 6f 62 74 61 |mportant| to obta|
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|00002f80| 6f 72 79 20 66 72 6f 6d | 20 6d 65 6e 20 73 63 68 |ory from| men sch|
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|000030a0| 50 6f 73 74 2d 43 6f 6d | 6d 65 6e 74 0d 0a 0d 0a |Post-Com|ment....|
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|000030f0| 20 6e 6f 74 20 72 65 63 | 65 69 76 69 6e 67 0d 0a | not rec|eiving..|
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|00003140| 20 6d 65 61 6e 20 61 67 | 65 20 77 61 73 0d 0a 61 | mean ag|e was..a|
|00003150| 62 6f 75 74 20 34 38 20 | 79 65 61 72 73 2e 20 20 |bout 48 |years. |
|00003160| 42 6f 74 68 20 70 72 6f | 70 72 61 6e 6f 6c 6f 6c |Both pro|pranolol|
|00003170| 20 61 6e 64 20 6d 65 74 | 68 79 6c 64 6f 70 61 2c | and met|hyldopa,|
|00003180| 20 61 73 20 6d 69 67 68 | 74 20 62 65 20 65 78 70 | as migh|t be exp|
|00003190| 65 63 74 65 64 20 66 72 | 6f 6d 0d 0a 74 68 65 69 |ected fr|om..thei|
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|00003230| 20 6c 61 74 74 65 72 0d | 0a 64 72 75 67 73 20 77 | latter.|.drugs w|
|00003240| 65 72 65 20 6e 6f 74 20 | 6e 6f 74 65 64 20 69 6e |ere not |noted in|
|00003250| 20 74 68 65 20 70 72 65 | 73 65 6e 74 20 73 74 75 | the pre|sent stu|
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|00003270| 66 66 69 63 75 6c 74 79 | 20 69 6e 20 6d 61 69 6e |fficulty| in main|
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|00003350| 6c 20 65 66 66 65 63 74 | 73 20 61 6e 64 20 74 6f |l effect|s and to|
|00003360| 20 74 72 79 20 74 6f 20 | 74 61 69 6c 6f 72 20 74 | try to |tailor t|
|00003370| 68 65 72 61 70 79 20 74 | 6f 0d 0a 70 72 6f 64 75 |herapy t|o..produ|
|00003380| 63 65 20 74 68 65 20 6c | 65 61 73 74 20 64 69 66 |ce the l|east dif|
|00003390| 66 69 63 75 6c 74 79 2e | 2d 2d 4c 2e 45 2e 20 48 |ficulty.|--L.E. H|
|000033a0| 6f 6c 6c 69 73 74 65 72 | 2c 20 4d 2e 44 2e 0d 0a |ollister|, M.D...|
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|00003410| 49 49 0d 0a 4d 69 6e 6f | 2c 20 52 44 7d 0d 0a 24 |II..Mino|, RD}..$|
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|00003430| 20 55 6e 69 76 2c 20 44 | 75 72 68 61 6d 2c 20 4e | Univ, D|urham, N|
|00003440| 43 7d 0d 0a 24 53 75 62 | 6a 65 63 74 7b 54 72 61 |C}..$Sub|ject{Tra|
|00003450| 7a 6f 64 6f 6e 65 20 70 | 72 69 61 70 69 73 6d 20 |zodone p|riapism |
|00003460| 61 66 74 65 72 3b 0d 0a | 50 72 69 61 70 69 73 6d |after;..|Priapism|
|00003470| 20 61 66 74 65 72 20 74 | 72 61 7a 6f 64 6f 6e 65 | after t|razodone|
|00003480| 7d 0d 0a 24 4a 6f 75 72 | 6e 61 6c 7b 4a 20 55 72 |}..$Jour|nal{J Ur|
|00003490| 6f 6c 6f 67 79 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b |ology}..|$Volume{|
|000034a0| 31 33 39 7d 0d 0a 24 50 | 61 67 65 7b 33 36 39 2d |139}..$P|age{369-|
|000034b0| 33 37 30 7d 0d 0a 24 44 | 61 74 65 7b 46 65 62 72 |370}..$D|ate{Febr|
|000034c0| 75 61 72 79 20 31 39 38 | 38 7d 0d 0a 24 59 42 56 |uary 198|8}..$YBV|
|000034d0| 6f 6c 7b 31 39 38 39 20 | 59 65 61 72 20 42 6f 6f |ol{1989 |Year Boo|
|000034e0| 6b 20 6f 66 20 44 72 75 | 67 20 54 68 65 72 61 70 |k of Dru|g Therap|
|000034f0| 79 7d 0d 0a 24 43 68 61 | 70 74 65 72 7b 33 2d 32 |y}..$Cha|pter{3-2|
|00003500| 32 7d 0d 0a 24 59 42 45 | 64 69 74 6f 72 7b 44 72 |2}..$YBE|ditor{Dr|
|00003510| 73 2e 20 48 6f 6c 6c 69 | 73 74 65 72 20 61 6e 64 |s. Holli|ster and|
|00003520| 20 4c 61 73 61 67 6e 61 | 7d 0d 0a 24 54 61 62 6c | Lasagna|}..$Tabl|
|00003530| 65 7b 7d 0d 0a 24 43 6f | 6d 6d 65 6e 74 61 74 6f |e{}..$Co|mmentato|
|00003540| 72 7b 4c 2e 20 4c 61 73 | 61 67 6e 61 2c 20 4d 2e |r{L. Las|agna, M.|
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|00003560| 20 28 63 29 20 59 65 61 | 72 20 42 6f 6f 6b 20 4d | (c) Yea|r Book M|
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|00003580| 73 2c 20 49 6e 63 2e 2c | 20 31 39 38 39 0d 0a 0d |s, Inc.,| 1989...|
|00003590| 0a 31 39 38 39 20 59 65 | 61 72 20 42 6f 6f 6b 20 |.1989 Ye|ar Book |
|000035a0| 6f 66 20 44 72 75 67 20 | 54 68 65 72 61 70 79 20 |of Drug |Therapy |
|000035b0| 28 52 29 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 33 |(R)....C|hapter 3|
|000035c0| 2d 2d 41 64 76 65 72 73 | 65 20 44 72 75 67 20 52 |--Advers|e Drug R|
|000035d0| 65 61 63 74 69 6f 6e 73 | 0d 0a 0d 0a 2d 2d 2d 2d |eactions|....----|
|000035e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000035f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003600| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003610| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003620| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 50 72 |--------|----..Pr|
|00003630| 69 61 70 69 73 6d 20 41 | 73 73 6f 63 69 61 74 65 |iapism A|ssociate|
|00003640| 64 20 57 69 74 68 20 54 | 72 61 7a 6f 64 6f 6e 65 |d With T|razodone|
|00003650| 20 54 68 65 72 61 70 79 | 0d 0a 0d 0a 43 61 72 73 | Therapy|....Cars|
|00003660| 6f 6e 20 43 43 20 49 49 | 49 2c 20 4d 69 6e 6f 20 |on CC II|I, Mino |
|00003670| 52 44 0d 0a 28 44 75 6b | 65 20 55 6e 69 76 2c 20 |RD..(Duk|e Univ, |
|00003680| 44 75 72 68 61 6d 2c 20 | 4e 43 29 0d 0a 4a 20 55 |Durham, |NC)..J U|
|00003690| 72 6f 6c 6f 67 79 20 31 | 33 39 3a 33 36 39 2d 33 |rology 1|39:369-3|
|000036a0| 37 30 2c 20 46 65 62 72 | 75 61 72 79 20 31 39 38 |70, Febr|uary 198|
|000036b0| 38 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |8..-----|--------|
|000036c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000036d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000036e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000036f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003700| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00003710| 0a 0d 0a 20 20 20 20 20 | 50 72 69 61 70 69 73 6d |... |Priapism|
|00003720| 20 61 6e 64 20 70 72 6f | 6c 6f 6e 67 65 64 20 65 | and pro|longed e|
|00003730| 72 65 63 74 69 6f 6e 20 | 61 73 73 6f 63 69 61 74 |rection |associat|
|00003740| 65 64 20 77 69 74 68 20 | 74 72 61 7a 6f 64 6f 6e |ed with |trazodon|
|00003750| 65 20 74 68 65 72 61 70 | 79 20 6f 63 63 75 72 72 |e therap|y occurr|
|00003760| 65 64 0d 0a 69 6e 20 32 | 20 70 61 74 69 65 6e 74 |ed..in 2| patient|
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|000037c0| 75 6c 61 74 69 6f 6e 2e | 20 20 42 6f 74 68 20 68 |ulation.| Both h|
|000037d0| 61 64 20 62 65 65 6e 20 | 74 61 6b 69 6e 67 20 74 |ad been |taking t|
|000037e0| 72 61 7a 6f 64 6f 6e 65 | 20 66 6f 72 20 64 65 70 |razodone| for dep|
|000037f0| 72 65 73 73 69 6f 6e 20 | 66 6f 72 20 32 2d 33 0d |ression |for 2-3.|
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|00003830| 20 36 30 30 20 6d 67 20 | 61 6e 64 20 32 30 30 20 | 600 mg |and 200 |
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|00003850| 2c 0d 0a 32 2d 33 20 64 | 61 79 73 20 62 65 66 6f |,..2-3 d|ays befo|
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|000038a0| 65 6e 74 0d 0a 61 66 74 | 65 72 20 74 68 65 72 65 |ent..aft|er there|
|000038b0| 20 77 61 73 20 6e 6f 20 | 72 65 73 70 6f 6e 73 65 | was no |response|
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|000039d0| 7a 6f 64 6f 6e 65 2c 20 | 61 20 74 72 69 61 7a 6f |zodone, |a triazo|
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|00003ab0| 64 20 62 6c 6f 6f 64 20 | 66 6c 6f 77 20 61 6e 64 |d blood |flow and|
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|00003b40| 65 6e 74 0d 0a 0d 0a 20 | 20 20 20 20 4f 6e 65 20 |ent.... | One |
|00003b50| 6f 66 20 74 72 61 7a 6f | 64 6f 6e 65 27 73 20 6d |of trazo|done's m|
|00003b60| 61 69 6e 20 73 65 6c 6c | 69 6e 67 20 70 6f 69 6e |ain sell|ing poin|
|00003b70| 74 73 20 69 73 20 69 74 | 73 20 72 65 6c 61 74 69 |ts is it|s relati|
|00003b80| 76 65 20 66 72 65 65 64 | 6f 6d 20 66 72 6f 6d 20 |ve freed|om from |
|00003b90| 74 68 65 0d 0a 6b 69 6e | 64 73 20 6f 66 20 73 69 |the..kin|ds of si|
|00003ba0| 64 65 20 65 66 66 65 63 | 74 73 20 73 6f 20 6f 66 |de effec|ts so of|
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|00003c00| 6e 73 65 71 75 65 6e 63 | 65 20 6f 66 20 74 61 6b |nsequenc|e of tak|
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|00003c20| 54 68 65 20 67 6f 6f 64 | 20 6e 65 77 73 20 69 73 |The good| news is|
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|00003c40| 20 72 61 72 65 2e 2d 2d | 4c 2e 20 4c 61 73 61 67 | rare.--|L. Lasag|
|00003c50| 6e 61 2c 20 4d 2e 44 2e | 0d 0a 24 55 6e 69 71 75 |na, M.D.|..$Uniqu|
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|00003c90| 63 61 74 69 6f 6e 73 20 | 61 6e 64 20 74 68 65 20 |cations |and the |
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|00003d10| 6f 62 73 6f 6e 2c 20 41 | 0d 0a 44 75 67 67 61 6e |obson, A|..Duggan|
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|00003d30| 6f 6e 7b 55 6e 69 76 20 | 6f 66 20 4e 65 77 63 61 |on{Univ |of Newca|
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|00003d50| 0d 0a 24 53 75 62 6a 65 | 63 74 7b 55 6c 63 65 72 |..$Subje|ct{Ulcer|
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|00003de0| 61 74 69 6e 67 3b 0d 0a | 41 73 70 69 72 69 6e 20 |ating;..|Aspirin |
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|00003e70| 24 50 61 67 65 7b 31 32 | 32 37 2d 31 32 32 39 7d |$Page{12|27-1229}|
|00003e80| 0d 0a 24 44 61 74 65 7b | 4e 6f 76 20 31 34 2c 20 |..$Date{|Nov 14, |
|00003e90| 31 39 38 37 7d 0d 0a 24 | 59 42 56 6f 6c 7b 31 39 |1987}..$|YBVol{19|
|00003ea0| 38 39 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |89 Year |Book of |
|00003eb0| 44 72 75 67 20 54 68 65 | 72 61 70 79 7d 0d 0a 24 |Drug The|rapy}..$|
|00003ec0| 43 68 61 70 74 65 72 7b | 33 2d 32 33 7d 0d 0a 24 |Chapter{|3-23}..$|
|00003ed0| 59 42 45 64 69 74 6f 72 | 7b 44 72 73 2e 20 48 6f |YBEditor|{Drs. Ho|
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|00003f10| 2e 20 48 6f 6c 6c 69 73 | 74 65 72 2c 20 4d 2e 44 |. Hollis|ter, M.D|
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|00003f50| 2c 20 49 6e 63 2e 2c 20 | 31 39 38 39 0d 0a 0d 0a |, Inc., |1989....|
|00003f60| 31 39 38 39 20 59 65 61 | 72 20 42 6f 6f 6b 20 6f |1989 Yea|r Book o|
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|00003f80| 52 29 0d 0a 0d 0a 43 68 | 61 70 74 65 72 20 33 2d |R)....Ch|apter 3-|
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|00003fb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003fc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003fd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003fe0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003ff0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 46 61 74 |--------|---..Fat|
|00004000| 61 6c 20 50 65 70 74 69 | 63 20 55 6c 63 65 72 20 |al Pepti|c Ulcer |
|00004010| 43 6f 6d 70 6c 69 63 61 | 74 69 6f 6e 73 20 61 6e |Complica|tions an|
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|00004040| 69 6e 66 6c 61 6d 6d 61 | 74 6f 72 79 0d 0a 44 72 |inflamma|tory..Dr|
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|00004060| 64 20 43 6f 72 74 69 63 | 6f 73 74 65 72 6f 69 64 |d Cortic|osteroid|
|00004070| 73 0d 0a 0d 0a 48 65 6e | 72 79 20 44 41 2c 20 4a |s....Hen|ry DA, J|
|00004080| 6f 68 6e 73 74 6f 6e 20 | 41 2c 20 44 6f 62 73 6f |ohnston |A, Dobso|
|00004090| 6e 20 41 2c 20 44 75 67 | 67 61 6e 20 4a 0d 0a 28 |n A, Dug|gan J..(|
|000040a0| 55 6e 69 76 20 6f 66 20 | 4e 65 77 63 61 73 74 6c |Univ of |Newcastl|
|000040b0| 65 2c 20 41 75 73 74 72 | 61 6c 69 61 29 0d 0a 42 |e, Austr|alia)..B|
|000040c0| 72 20 4d 65 64 20 4a 20 | 32 39 35 3a 31 32 32 37 |r Med J |295:1227|
|000040d0| 2d 31 32 32 39 2c 20 4e | 6f 76 20 31 34 2c 20 31 |-1229, N|ov 14, 1|
|000040e0| 39 38 37 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |987..---|--------|
|000040f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004110| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004120| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004be0| 35 39 7d 0d 0a 24 44 61 | 74 65 7b 4a 75 6e 65 20 |59}..$Da|te{June |
|00004bf0| 31 39 38 37 7d 0d 0a 24 | 59 42 56 6f 6c 7b 31 39 |1987}..$|YBVol{19|
|00004c00| 38 39 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |89 Year |Book of |
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|00004c20| 43 68 61 70 74 65 72 7b | 33 2d 32 34 7d 0d 0a 24 |Chapter{|3-24}..$|
|00004c30| 59 42 45 64 69 74 6f 72 | 7b 44 72 73 2e 20 48 6f |YBEditor|{Drs. Ho|
|00004c40| 6c 6c 69 73 74 65 72 20 | 61 6e 64 20 4c 61 73 61 |llister |and Lasa|
|00004c50| 67 6e 61 7d 0d 0a 24 54 | 61 62 6c 65 7b 7d 0d 0a |gna}..$T|able{}..|
|00004c60| 24 43 6f 6d 6d 65 6e 74 | 61 74 6f 72 7b 4c 2e 20 |$Comment|ator{L. |
|00004c70| 4c 61 73 61 67 6e 61 2c | 20 4d 2e 44 2e 7d 0d 0a |Lasagna,| M.D.}..|
|00004c80| 0d 0a 43 6f 70 79 72 69 | 67 68 74 20 28 63 29 20 |..Copyri|ght (c) |
|00004c90| 59 65 61 72 20 42 6f 6f | 6b 20 4d 65 64 69 63 61 |Year Boo|k Medica|
|00004ca0| 6c 20 50 75 62 6c 69 73 | 68 65 72 73 2c 20 49 6e |l Publis|hers, In|
|00004cb0| 63 2e 2c 20 31 39 38 39 | 0d 0a 0d 0a 31 39 38 39 |c., 1989|....1989|
|00004cc0| 20 59 65 61 72 20 42 6f | 6f 6b 20 6f 66 20 44 72 | Year Bo|ok of Dr|
|00004cd0| 75 67 20 54 68 65 72 61 | 70 79 20 28 52 29 0d 0a |ug Thera|py (R)..|
|00004ce0| 0d 0a 43 68 61 70 74 65 | 72 20 33 2d 2d 41 64 76 |..Chapte|r 3--Adv|
|00004cf0| 65 72 73 65 20 44 72 75 | 67 20 52 65 61 63 74 69 |erse Dru|g Reacti|
|00004d00| 6f 6e 73 0d 0a 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d |ons....-|--------|
|00004d10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004d20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004d30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004d40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004d50| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 54 68 65 20 52 65 6c |-------.|.The Rel|
|00004d60| 61 74 69 76 65 20 47 61 | 73 74 72 6f 69 6e 74 65 |ative Ga|strointe|
|00004d70| 73 74 69 6e 61 6c 20 54 | 6f 78 69 63 69 74 79 20 |stinal T|oxicity |
|00004d80| 6f 66 20 74 68 65 20 4e | 6f 6e 73 74 65 72 6f 69 |of the N|onsteroi|
|00004d90| 64 61 6c 20 41 6e 74 69 | 2d 69 6e 66 6c 61 6d 6d |dal Anti|-inflamm|
|00004da0| 61 74 6f 72 79 0d 0a 44 | 72 75 67 73 0d 0a 0d 0a |atory..D|rugs....|
|00004db0| 43 61 72 73 6f 6e 20 4a | 4c 2c 20 53 74 72 6f 6d |Carson J|L, Strom|
|00004dc0| 20 42 4c 2c 20 4d 6f 72 | 73 65 20 4d 4c 2c 20 57 | BL, Mor|se ML, W|
|00004dd0| 65 73 74 20 53 4c 2c 20 | 53 6f 70 65 72 20 4b 41 |est SL, |Soper KA|
|00004de0| 2c 20 53 74 6f 6c 6c 65 | 79 20 50 44 2c 20 4a 6f |, Stolle|y PD, Jo|
|00004df0| 6e 65 73 20 4a 4b 0d 0a | 28 55 6e 69 76 20 6f 66 |nes JK..|(Univ of|
|00004e00| 20 50 65 6e 6e 73 79 6c | 76 61 6e 69 61 2c 20 50 | Pennsyl|vania, P|
|00004e10| 68 69 6c 61 64 65 6c 70 | 68 69 61 3b 20 55 6e 69 |hiladelp|hia; Uni|
|00004e20| 76 20 6f 66 20 4d 65 64 | 69 63 69 6e 65 20 61 6e |v of Med|icine an|
|00004e30| 64 20 44 65 6e 74 69 73 | 74 72 79 20 6f 66 20 4e |d Dentis|try of N|
|00004e40| 65 77 0d 0a 4a 65 72 73 | 65 79 2f 52 6f 62 65 72 |ew..Jers|ey/Rober|
|00004e50| 74 20 57 6f 6f 64 20 4a | 6f 68 6e 73 6f 6e 20 4d |t Wood J|ohnson M|
|00004e60| 65 64 20 53 63 68 6f 6f | 6c 2c 20 43 61 6d 64 65 |ed Schoo|l, Camde|
|00004e70| 6e 2c 20 4e 4a 3b 20 48 | 65 61 6c 74 68 20 49 6e |n, NJ; H|ealth In|
|00004e80| 66 6f 72 6d 61 74 69 6f | 6e 20 44 65 73 69 67 6e |formatio|n Design|
|00004e90| 73 0d 0a 49 6e 63 2c 20 | 41 72 6c 69 6e 67 74 6f |s..Inc, |Arlingto|
|00004ea0| 6e 2c 20 56 61 3b 20 74 | 68 65 20 46 6f 6f 64 20 |n, Va; t|he Food |
|00004eb0| 61 6e 64 20 44 72 75 67 | 20 41 64 6d 69 6e 69 73 |and Drug| Adminis|
|00004ec0| 74 72 61 74 69 6f 6e 2c | 20 57 61 73 68 69 6e 67 |tration,| Washing|
|00004ed0| 74 6f 6e 2c 20 44 43 29 | 0d 0a 41 72 63 68 20 49 |ton, DC)|..Arch I|
|00004ee0| 6e 74 65 72 6e 20 4d 65 | 64 20 31 34 37 3a 31 30 |ntern Me|d 147:10|
|00004ef0| 35 34 2d 31 30 35 39 2c | 20 4a 75 6e 65 20 31 39 |54-1059,| June 19|
|00004f00| 38 37 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |87..----|--------|
|00004f10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004f20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004f30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004f40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004f50| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|00004f60| 0d 0a 0d 0a 20 20 20 20 | 20 52 65 63 65 6e 74 20 |.... | Recent |
|00004f70| 63 6c 69 6e 69 63 61 6c | 20 65 70 69 64 65 6d 69 |clinical| epidemi|
|00004f80| 6f 6c 6f 67 69 63 20 73 | 74 75 64 69 65 73 20 68 |ologic s|tudies h|
|00004f90| 61 76 65 20 63 6f 6e 66 | 69 72 6d 65 64 20 61 6e |ave conf|irmed an|
|00004fa0| 20 61 73 73 6f 63 69 61 | 74 69 6f 6e 20 6f 66 0d | associa|tion of.|
|00004fb0| 0a 6e 6f 6e 73 74 65 72 | 6f 69 64 61 6c 20 61 6e |.nonster|oidal an|
|00004fc0| 74 69 2d 69 6e 66 6c 61 | 6d 6d 61 74 6f 72 79 20 |ti-infla|mmatory |
|00004fd0| 64 72 75 67 73 20 28 4e | 53 41 49 44 73 29 20 61 |drugs (N|SAIDs) a|
|00004fe0| 6e 64 20 75 70 70 65 72 | 20 67 61 73 74 72 6f 69 |nd upper| gastroi|
|00004ff0| 6e 74 65 73 74 69 6e 61 | 6c 20 28 55 47 49 29 0d |ntestina|l (UGI).|
|00005000| 0a 74 72 61 63 74 20 62 | 6c 65 65 64 69 6e 67 2e |.tract b|leeding.|
|00005010| 20 20 54 68 65 20 72 65 | 6c 61 74 69 76 65 20 72 | The re|lative r|
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